Important Safety Information: Semaglutide with NAD+ (Glucagon-Like Peptide-1 Receptor Agonist with Nicotinamide Adenine Dinucleotide) | Compounded Injectable

What is this?

This Important Safety Information summarizes key warnings and precautions for Semaglutide/NAD+, a compounded injectable formulation. Semaglutide is a GLP-1 receptor agonist that works by mimicking natural incretin hormones to support appetite regulation, gastric emptying, and metabolic balance. Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme involved in cellular energy production and antioxidant processes.

This compounded combination may be prescribed for weight management support in certain patients when deemed clinically appropriate. This compounded formulation has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. It should only be used exactly as directed by a licensed healthcare provider.

This summary does not include all available information. Always read your medication label and follow your provider’s instructions.

Most Serious Warnings

Product can cause:

• Severe allergic reactions, including anaphylaxis

• Pancreatitis, which may present as severe abdominal pain that does not go away

• Possible thyroid C-cell tumors, including medullary thyroid carcinoma observed in animal studies

• Worsening depression or suicidal thoughts

• Low blood sugar (especially when used with insulin or other diabetic medications)

• Severe gastrointestinal reactions, including persistent vomiting or dehydration

Compounded Semaglutide/NAD+ may carry sterility or formulation risks due to limited FDA oversight.

Who Should NOT Take Semaglutide/NAD+

Do not take this medication if you:

• Have a known allergy to semaglutide, NAD+, or any ingredient in the formulation

• Have a personal or family history of medullary thyroid carcinoma

• Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

• Have a history of pancreatitis unless cleared by your provider

• Are currently using another GLP-1 receptor agonist

• Are pregnant

Before Taking Semaglutide/NAD+, Tell Your Healthcare Provider if You:

• Have ever had pancreatitis

• Have a history of thyroid disease

• Have depression, mood disorders, or thoughts of self-harm

• Have diabetes or use insulin or oral diabetic medications

• Take blood thinners or cardiovascular medications

• Take thyroid medication

• Take opioid pain relievers

• Take antibiotics or antidepressants

• Have kidney problems or dehydration

• Are breastfeeding or planning pregnancy

• Take prescription, over-the-counter, herbal products, or supplements

Do not start, stop, or change the dose of any medication without checking with your provider.

Possible Side Effects

Common (mild to moderate):

• Constipation or diarrhea

• Nausea or vomiting

• Stomach pain or bloating

• Gas or burping

• Headache

• Dizziness, fatigue, or weakness

• Nose or throat irritation

• Injection site irritation

Serious (seek medical care immediately):

• Swelling of the face, lips, tongue, or throat

• Difficulty breathing

• Severe abdominal pain that may radiate to the back

• Neck mass, trouble swallowing, hoarseness that does not go away

• Severe mood changes or suicidal thoughts

• Signs of low blood sugar such as confusion, shaking, sweating, or fainting

While Taking Semaglutide/NAD+

Tell your healthcare provider immediately if you:

• Experience persistent or severe abdominal pain

• Notice a lump or swelling in your neck

• Develop unusual mood changes

• Experience symptoms of low blood sugar

• Have severe nausea, vomiting, or signs of dehydration

• Develop symptoms suggesting an allergic reaction

Pregnancy and Fertility

This medication is not recommended during pregnancy. Weight loss medications may harm an unborn baby. Inform your provider immediately if you become pregnant. The safety of this compounded formulation during breastfeeding has not been established.

Overdose

Symptoms of overdose may include:

• Severe nausea or vomiting

• Severe dehydration

• Low blood sugar

• Dizziness or fainting

If overdose is suspected, seek emergency medical attention or contact Poison Control right away.

Missed Dosage

If you miss a scheduled dose:

• Take the missed dose when remembered unless it is close to your next scheduled dose

• Skip the missed dose if it is near the next dose

• Do not double the next dose

• Contact your provider if unsure how to resume therapy

Storage

• Refrigerate as instructed on your prescription label

• Do not freeze

• Protect from light

• Do not use if solution is cloudy, leaking, discolored, or contains particles

• Keep out of reach of children and pets

Medication Disposal

Dispose of needles in a proper sharps container. Do not reuse needles. Dispose of unused or expired medication according to local medication disposal guidelines. Do not flush medication or dispose of it in household drains.

Provider Oversight and Order Review

This compounded medication requires review and oversight by licensed Superior Health and Wellness providers. Dosing and therapy schedules must be discussed directly with your provider to ensure safety and clinical appropriateness. Orders may be adjusted based on labs, clinical response, and patient eligibility.

Telemedicine Disclosure

This prescription may be issued via telemedicine. If you experience concerning or severe symptoms, contact your prescribing clinician immediately or seek emergency medical care.

Disclaimer

This summary does not include all information about Semaglutide/NAD+ and should not replace medical guidance. Always consult your healthcare provider or pharmacist for complete safety information, potential interactions, and individualized treatment recommendations. This compounded medication has not been evaluated or approved by the FDA for safety or efficacy.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.