The Role of Testosterone in Women’s Health: Addressing Fatigue, Libido & Cognitive Changes Safely
*Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult your provider for individualized care and prescriptions.
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Testosterone is often associated with men’s health, but it plays a crucial role in women’s well-being as well. Produced in the ovaries and adrenal glands, testosterone contributes to various physiological functions in women, including energy levels, libido, and cognitive function. As women age, particularly during perimenopause and menopause, testosterone levels naturally decline, leading to symptoms such as fatigue, reduced sexual desire, and cognitive changes. Understanding the role of testosterone in women's health and exploring safe therapeutic options can help address these concerns effectively.¹,²
Understanding Testosterone’s Role in Women’s Health
Testosterone is an androgen hormone that, while present in lower amounts than in men, is vital for several bodily functions in women. It contributes to muscle strength, bone density, mood regulation, and sexual function. During reproductive years, testosterone levels fluctuate but remain relatively stable. However, as women approach menopause, typically between ages 45 and 55, testosterone levels begin to decline, which can lead to various symptoms.¹,³
Common Symptoms of Low Testosterone in Women
Women experiencing low testosterone levels may encounter several symptoms that impact daily life:
Fatigue and Low Energy: A decrease in testosterone can lead to feelings of tiredness and low energy, affecting overall productivity and quality of life.¹
Reduced Libido: Testosterone plays a significant role in sexual desire. Lower levels can result in decreased interest in sexual activity and satisfaction.¹,²
Cognitive Changes: Some women report difficulties with concentration, memory, and mental clarity, often referred to as "brain fog."²
Mood Fluctuations: Low testosterone levels have been associated with mood swings, irritability, and even symptoms of depression.²
Decreased Muscle Mass and Bone Density: Testosterone helps maintain muscle mass and bone strength. A decline can lead to muscle weakness and an increased risk of osteoporosis.³
Can Testosterone Therapy Be a Safe and Effective Option for Women?
Testosterone replacement therapy (TRT) has been studied for its potential benefits in women with low testosterone levels. Research indicates that TRT can improve several aspects of health:
Improved Sexual Function: A systematic review and meta-analysis found that testosterone supplementation improved sexual desire, arousal, and satisfaction in postmenopausal women.³
Enhanced Mood and Cognitive Function: A pilot study suggested that transdermal testosterone therapy for four months was associated with significant improvements in mood and cognition in peri- and postmenopausal women.²
Increased Energy Levels: Testosterone therapy has been linked to increased energy and reduced fatigue in women experiencing low testosterone levels.⁴
Maintenance of Muscle Mass and Bone Density: Testosterone plays a role in preserving muscle mass and bone density, which can be beneficial in preventing osteoporosis and sarcopenia.⁵
Safety Considerations & Monitoring
While testosterone therapy can offer significant benefits, it is essential to approach treatment cautiously and under medical supervision. The only evidence-based indication for testosterone therapy in women is for the treatment of hypoactive sexual desire disorder after menopause.⁶ Before initiating therapy, healthcare providers typically assess baseline testosterone levels and consider potential risks.
Monitoring during therapy is crucial to ensure safety and efficacy. Regular follow-up appointments allow healthcare providers to adjust dosages and address any side effects promptly. Common side effects may include acne, hair growth, and voice deepening, although these are rare when therapy is administered correctly.⁷,⁸
Forms of Testosterone Therapy for Women
Testosterone therapy is available in various forms, allowing for personalized treatment plans:
Transdermal Patches and Gels: Applied to the skin, these methods provide a steady release of testosterone.⁷
Intramuscular Injections: Administered directly into the muscle, offering a controlled release of the hormone.⁷
Subcutaneous Pellets: Inserted under the skin, these pellets release testosterone over several months.⁵
Sublingual Tablets: Dissolved under the tongue, providing an alternative for those who prefer oral administration.⁷
The choice of therapy depends on individual preferences, medical history, and healthcare provider recommendations.
To understand which testosterone options are safest and most effective for your goals, talk with your Superior Health provider. While many forms of therapy exist, not all are offered at Superior Health and Wellness. Your provider can walk you through the options we do offer, explain the differences, and help determine the right fit based on your symptoms, labs, and preferences.
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When to Talk to a Provider
Testosterone plays a vital role in women's health, influencing energy levels, sexual function, and cognitive abilities. As women age, maintaining balanced testosterone levels becomes increasingly important. Testosterone therapy, when appropriately administered and monitored, can offer significant improvements in quality of life for women experiencing symptoms related to low testosterone. Consulting with a healthcare provider specializing in hormone therapy can help determine if testosterone therapy is a suitable option.
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References
Scott, A., et al. (2020). Should we be prescribing testosterone to perimenopausal women? Post Reproductive Health, 26(1), 3–13.
Glynne, S. (2024). Effect of transdermal testosterone therapy on mood and cognition in peri- and postmenopausal women: A pilot study. Women’s Mental Health, 27(1), 45–52.
Jayasena, C. N., et al. (2019). A systematic review of randomized controlled trials evaluating the effects of testosterone therapy in women. Clinical Endocrinology, 90(6), 1031–1041.
MacArthur Medical Center. (2024). Can women boost sex drive, energy, and brain function with testosterone therapy?
Hernandez, B. S., et al. (2025). Long-term testosterone pellet insertion in women with low libido shows no evidence of erythrocytosis and a minimal side effect profile. Translational Andrology and Urology, 14(7), 1842–1848.
Adams, J. P. (2019). Safety and efficacy of testosterone for women: A systematic review and meta-analysis. Oregon Health & Science University.
Glaser, R. (2013). Testosterone therapy in women: Myths and misconceptions. Maturitas, 74(2), 103–107.
Hone Health. (2024). 7 benefits of testosterone for women in menopause.
