Levothyroxine and Liothyronine Combination | Oral Tablets
Important Safety Information: Levothyroxine and Liothyronine Combination | Oral Tablets
What is this?
This Important Safety Information summarizes key warnings and precautions for levothyroxine (T4) and liothyronine (T3) combined in a single oral thyroid hormone tablet. This medication contains both T4 and T3 and is used as replacement or supplemental therapy in patients with hypothyroidism and certain thyroid-related conditions. Thyroid hormones regulate metabolism, energy production, cardiovascular function, and neurologic development. This summary is based on manufacturer labeling for the combined levothyroxine and liothyronine tablet and does not include all available information. Always read your medication label and follow your provider’s instructions.
Most Serious Warnings
Product can cause:
Severe allergic reactions, including rash, hives, swelling of the face, lips, tongue, or throat
Chest pain, rapid or irregular heartbeat, palpitations, or worsening angina
Shortness of breath or symptoms of heart failure
Signs of hyperthyroidism due to excessive dosing, including nervousness, tremors, sweating, heat intolerance, or significant weight loss
Mood changes, agitation, or neurological symptoms
Bone loss with long-term overtreatment
Thyroid hormones must not be used for weight loss in patients with normal thyroid function. Higher-than-recommended doses may cause serious or life-threatening toxicity .
Who Should NOT Take This Combination Medication
Do not take this medication if you:
Have untreated adrenal insufficiency
Have untreated thyrotoxicosis (overactive thyroid)
Have a known hypersensitivity to levothyroxine, liothyronine, or any ingredient in the formulation
Before Taking This Medication, Tell Your Healthcare Provider if You:
Have heart disease, angina, prior heart attack, or arrhythmias
Have high blood pressure
Have diabetes or use insulin or oral hypoglycemics
Take blood thinners such as warfarin
Take estrogen-containing medications or oral contraceptives
Take cholestyramine, colestipol, or other medications that may interfere with thyroid hormone absorption
Take biotin or biotin-containing supplements
Are pregnant, planning pregnancy, or breastfeeding
Have a history of osteoporosis
Possible Side Effects
Common (usually related to excessive dose):
Rapid heartbeat or palpitations
Nervousness or irritability
Sweating or heat intolerance
Tremor
Increased appetite or weight changes
Temporary hair loss in children during early therapy
Serious (seek medical care immediately):
Chest pain or pressure
Severe shortness of breath
Fainting or severe dizziness
Signs of severe allergic reaction
Confusion or severe agitation
While Taking This Combination Medication
Tell your healthcare provider immediately if you:
Develop chest pain, rapid or irregular heartbeat
Experience new or worsening shortness of breath
Notice severe anxiety, tremors, or excessive sweating
Have symptoms of blood sugar changes if you have diabetes
Experience unusual bleeding or bruising while on anticoagulants
Pregnancy and Breastfeeding
Thyroid hormone replacement therapy is generally continued during pregnancy in patients with hypothyroidism. Dose adjustments may be necessary. Small amounts of thyroid hormone may be present in breast milk. Discuss risks and benefits with your provider .
Overdose
Symptoms of overdose may resemble hyperthyroidism and can include:
Rapid or irregular heartbeat
Chest pain
Excessive sweating
Nervousness or agitation
Fever
Tremors
If overdose is suspected, seek emergency medical attention or contact Poison Control right away.
Missed Dosage
If you miss a dose:
Take it as soon as you remember unless it is close to your next scheduled dose
Do not double your next dose
Contact your provider if you are unsure how to resume therapy
Storage
Store at controlled room temperature
Protect from light and moisture
Keep out of reach of children
Medication Disposal
Dispose of unused or expired medication according to local medication disposal guidelines. Do not flush medication or dispose of it in household drains. Contact your pharmacy for disposal instructions or ask about medication take-back programs.
Provider Oversight and Order Review
Thyroid hormone therapy requires individualized dosing based on clinical response and laboratory monitoring, including TSH and thyroid hormone levels . Dose adjustments should only be made under the supervision of a licensed healthcare provider.
Telemedicine Disclosure
This prescription may be issued via telemedicine. If you experience concerning or severe symptoms, contact your prescribing clinician immediately or seek emergency medical care.
Disclaimer
This summary does not include all information about levothyroxine and liothyronine combination medication and does not replace medical advice. Always consult your healthcare provider or pharmacist for complete safety information, potential drug interactions, and individualized treatment recommendations. This medication is a prescription drug approved by the U.S. Food and Drug Administration; however, this summary is not the full prescribing information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.
